Dr. George Nogradi

Professor of Rec and Leisure Studies.

Synthesis of 4-hydroxycinnamic amides of di-, tri-, and tetraamines : potential insect toxins /

The monoconjugates of phenolic acids (i.e. coumaric acid) with polyamines such as spermidine and spermine are strikingly similar to some toxins from spiders and predatory wasps. Many plants contain phenolic acid polyamine conjugates and there is some reliable information supporting their roles as plant defense chemicals. Eleven monoacylated compounds of diamines, triamines, tetraamines and oxa-polyamine amines were prepared in three to seven steps: 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 and 32. The synthesis proceeds through stepwise construction of the polyamine backbone (as in 62 and 72), followed by protection and deprotection steps of the amino functions. Desymmetrization of readily available and prepared symmetrical polyamines is a key step in the synthesis. The protecting groups employed were tert-butoxycarbonyl (BOC) and trifluoroacetyl (TFA) group which were removed under different conditions: acid and base respectively. Deprotection and refunctionalization of the polyamine reagent demonstrated the versatility of these systems for N-acylation.

Timing of di-ammonium phosphate addition to fermenting chardonnay must : effect on nitrogen utilization, ethyl-carbamate formation, and CAR1 expression by yeast /

The maximum amount of ethyl carbamate (EC), a known animal carcinogen produced by the reaction of urea and ethanol, allowed in alcoholic beverages is regulated by legislation in many countries. Wine yeast produce urea by the metabolism of arginine, the predominant assimilable amino acid in must. This action is due to arginase (encoded by CARl). Regulation of CARl, and other genes in this pathway, is often attributed to a well-documented phenomenon known as nitrogen catabolite repression. The effect of the timing of di-ammonium phosphate (DAP) additions on the nitrogen utilization, regulation of CARl, and EC production was investigated. A correlation was found between the timing of DAP addition and the utilization of nitrogen. When DAP was added earlier in the fermentations, less amino nitrogen and more ammonia nitrogen was sequestered from the media by the cells. It was also seen that early DAP addition led to more total nitrogen being used, with a maximal difference of ~25% between fermentations where no DAP was added versus addition at the start of the fermentation. The effect of the timing ofDAP addition on the expression of CARJ during fermentation was analyzed via northern transfer and the relative levels of CARl expression were determined. The trends in expression can be correlated to the nitrogen data and be used to partially explain differences in EC formation between the treatments. EC was quantified at the end of fermentation by GC/MS. In Montrachet yeast, a significant positive correlation was found between the timing of DAP addition, from early to late, and the final EC concentration m the wine (r = 0.9226). In one of the fermentations, EC levels of 30.5 ppb was foimd when DAP was added at the onset of fermentation. A twofold increase (69.5 ppb) was observed when DAP was added after 75% of the sugars were metabolized. When no DAP was added, the ethyl carbamate levels are comparable at a value of 38 ppb. In contrast, the timing of DAP additions do not affect the level EC produced by the yeast ECU 18 in this manner. The study of additional yeast strains shows that the effect of DAP addition to fermentations is strain dependent. Our results reveal the potential importance of the timing of DAP addition to grape must with respect to EC production, and the regulatory effect of DAP additions on the expression of genes in the pathway for arginine metabolism in certain wine yeast strains.

Is technology a threat to education? : the contribution of George Parkin Grant

Thesis (M.Ed.)-- Brock University, 1995.

Oath of Allegiance to King George III

Transcript (original spelling and grammar retained): We the Commissioned Officers belonging to the Second Regiment of Lincoln Militia - Do sincerely promise and swear that we will be faithful and bear true allegiance to his Majesty King George, and heirs will defend to the utmost of our power against all traitorous conspiracies and attempts whatsoever which shall be made against his Person, Crown or Dignity; and we will do our utmost endeavours to disclose and make them known to his Majesty, His Heirs and successors, all treasons and traitorous conspiracies and attempts, which we shall know to be against Him or them. So help us God. Thomas Clark - Lt. Col. David Secord - Major John Crysler - Capt James Macklin - Capt John [Ross] - [Captain] [Abraham] Bowman - Lieut Gilbert McMicking - Quartmaster John [Misiner] - Ensign Robert Campbell - Capt John [Couke] - Ensign Nicholas Smith - Lieut I certify that the officers who have here [subscribed] the oath took it before me at Chippawa 4 Sept 1812 Thomas Dickson JP

Letter from George W. Campbell, esq., late Secretary of the Treasury, to the Chairman of the Committee appointed to inquire into the causes and particulars of the invasion of the City of Washington, and the neighboring town of Alexandria, in the month of August last. --

Laid before the House by the Chairman of the said Committee, and ordered to be printed January 2, 1815.

Robert George Malcomson Papers, 1790s-2009 (non-inclusive)

Materials related to military and naval operations of the 1812 era, research of the late Robert Malcomson, Canadian author and historian. Materials include photocopies of materials relating to the War of 1812, photographs and detailed research notes Malcomson made regarding his approach to research (mainly found in Series VIII). Materials were originally arranged in binders relating to an area of research or a certain publication. Articles were removed from the binders and placed in folders using original titles from the binders as series or sub-series titles. Articles within the binders were separated by tabs indicating what the article related to in the publication or topic of interest. In order to avoid repetition, the writing on the tab was used for folder titles, as each folder would be a part of the Series under which it was grouped. The tab names could be authors, events, accounts etc. of the War. Series and sub-series titles were derived from the original titles on the binders. Original intellectual order was retained, grouping similar subjects into Series and Sub-series. Dates recorded were the publication dates of the articles; however, if no publication date was present the date of retrieval was used if from an academic database (ex. JSTOR). The black and white photos from various repositories are reproductions of paintings, microfilm etc. on photographic paper. The colour photographs from various repositories are actual photographs. All books donated by Malcomson were integrated into the University’s Special Collections book collection. These volumes are noted at the end of the finding aid under separated materials.

George H. Cornish Fonds

George Henry Cornish (1834-1912) was a Methodist minister whose circuits included Clinton, Ont. (1859), Newcastle, Ont. (1861), and Caledonia/Binbrook/Glanford, Ont. (1864- 1865). He wrote several books on the Methodist Church in Canada, including the Cyclopaedia of Methodism in Canada (1881) and the Handbook of Canadian Methodism (1867).

Welland Canal Survey of Lands George Adams Esquire 1827

Survey map and description of George Adams' land created by The Welland Canal Company. Included is a written description of the land along with a drawing of the land. Noteable features include; Concession lines between the 4th and 5th concession and the 5th and 6th concession, canal. Surveyor notes are seen in pencil on the map. The deed for the land is dated May 10th 1827.See also page 41.

Welland Canal Survey of Lands George Adams Esquire 1835

Survey map and description of George Adam's land created by The Welland Canal Company. Included is a written description of the land along with a drawing of the land. Noteable features include; lock no.4, channel of 12 mile creek, road, canal, dock yard, Hayward Distillery, bridge. Surveyor notes are seen in pencil on the map. The land was a total of 3 acres including the creek.See also record for page 36. The land was required for canal towpath and lock house.

Welland Canal Survey of Lands George Keefer Esquire

Survey map and description of George Keefer's land created by The Welland Canal Company. Included is a written description of the land along with a drawing of the land. Noteable features include; road, road allowance, line between Black and Keefer's land, township line, reservoir, bridges, lock no's. 32, 33, 34, 35, mill. Surveyor notes are seen in pencil on the map. Land is composed of sections of lot no.s 9 and 17 in Thorold. The land is a total of 28 acres, 2 roads, and 12 perches.

Welland Canal Survey of Lands George Marlatt 1826, 1831

Two survey maps and descriptions of George Marlatt's land created by The Welland Canal Company. The first is from 1826, as described in the deed of November 21, 1826. The second survey was done on August 29, 1831 by George Keefer. Included is a written description of the land along with a drawing of the land. Noteable features for the first survey (p.85) include; line between Kelly and Marlatt's land, lot division. Noteable features for the second survey (p.87) include; road to Beaverdams, reservoir, bridges, road allowance, lot divisions, line between Kelly and Marlatt's land. Surveyor notes are seen in pencil on the map.See also Page 90-91

Welland Canal Survey of Lands George Marlatt 1826

Survey map and description of George Marlatt's land created by The Welland Canal Company. Included is a written description of the land along with a drawing of the land. Noteable features include; line between Wilson and Marlatt's land, canal. The land in total is 2 acres and includes part of a road. The deed for the land is dated November 21st, 1826. Surveyor notes are seen in pencil on the map.See also Pp.85-87.

Portrait of "Ruth", by George A. Hemstreet, Photographer, Milton [n.d.]

A woman identified only by the broach at her neck as "Ruth" is pictured here in a black and white cabinet card photograph by G. A. Hemstreet. The photo is undated, but believed to be from the late 1870s or early 1880s. The photographer's name is stamped in black ink along the bottom of the card: "G. A. Hemstreet, Photographer, Milton, Ont." This cabinet card was in the possession of Iris Sloman Bell, of St. Catharines, whose relatives include former Black slaves from the United States.G. A. Hemstreet, also known as George A. Hemstreet, was a photographer in Milton, Ontario from 1877 - 1887. Source: Phillips, Glen C. The Ontario photographers list (1851-1900). Sarnia: Iron Gate Publishing Co., 1990.